I’ve been using Vim for anywhere between 5 and 10 years, and my .vimrc is all grown up. I use {{{1 to annotate folds in my .vimrc, and use zM to close all folds and zR to open all folds (zc, zo, and za respectively close, open, and toggle individual folds). The --- lines are simply cosmetic.

" => Pre-load ------------------------------------------------------------- {{{1

set nocompatible  " Required for many plugins, ensures it's not compatible with 
                  " Vi, which nobody uses at this point.
filetype plugin indent on  " Great answer: https://vi.stackexchange.com/a/10125

Vundle is downright fantastic plugin manager. It allows one to install plugins with :PluginInstall and upgrade plugins with :PluginUpdate. Simple, easy, reliable. Of course you’ll need to have Vundle installed, which I normally have as a git submodule.

" Required Vundle setup.
set runtimepath+=~/.vim/bundle/vundle
set runtimepath+=$GOROOT/misc/vim
call vundle#rc()

" => Vundle plugins ------------------------------------------------------- {{{1

Plugin 'gmarik/vundle' " The Vundle itself, to keep itself updated.

" Colorschemes:
Plugin 'NLKNguyen/papercolor-theme'
Plugin 'ajh17/Spacegray.vim.git'
Plugin 'altercation/vim-colors-solarized'
Plugin 'squarefrog/tomorrow-night.vim'
Plugin 'vim-scripts/ScrollColors'  " Allows scrolling through colorschemes.

" Language/tool integration and support:
Plugin 'burnettk/vim-angular'
Plugin 'fatih/vim-go'
Plugin 'christoomey/vim-tmux-navigator'
Plugin 'mileszs/ack.vim'
Plugin 'motemen/git-vim'
Plugin 'nvie/vim-flake8'
Plugin 'pangloss/vim-javascript'
Plugin 'scrooloose/syntastic.git'  " Syntax checker.
Plugin 'tpope/vim-fugitive.git'    " Even better Git support.

" Quality of life:
Plugin 'EinfachToll/DidYouMean'    " For typos during opening files.
Plugin 'ciaranm/detectindent'      " Automatically detect indent.
Plugin 'ervandew/supertab'         " Smarter autocompletion.
Plugin 'junegunn/goyo.vim'         " A plugin for writing prose.
Plugin 'majutsushi/tagbar'         " List tags in a sidebar.
Plugin 'scrooloose/nerdtree'       " A directory tree in a sidebar.
Plugin 'tomtom/tcomment_vim'       " Easy comment blocks with <Leader>cc.
Plugin 'tpope/vim-abolish'         " Extended abbreviation/substition.
Plugin 'tpope/vim-repeat'          " Intelligent repeat with '.'
Plugin 'tpope/vim-surround'        " Work with pairs of quotes/anything.
Plugin 'tpope/vim-unimpaired.git'  " Handy bracket mappings.
Plugin 'tpope/vim-vinegar'         " Enhanced directory browser.
Plugin 'vim-scripts/DirDiff.vim'   " Directory level diff.

" New features:
Plugin 'Lokaltog/vim-easymotion'   " Easy navigation with <Leader><Leader>w.
Plugin 'kien/ctrlp.vim'            " Hit <C>p for a list of files/buffers.
Plugin 'vim-scripts/Gundo.git'     " Intelligent undo tree.
Plugin 'vim-scripts/vimwiki'       " A personal local Wiki.

if v:version > 703
  Plugin 'SirVer/ultisnips'        " Intricate snippets.
  Plugin 'chrisbra/vim-diff-enhanced'

" => Plugins configuration ------------------------------------------------ {{{1

" NERDTree: auto close if last window.
function! s:CloseIfOnlyNerdTreeLeft()
  if exists("t:NERDTreeBufName")
    if bufwinnr(t:NERDTreeBufName) != -1
      if winnr("$") == 1

" Force Gundo preview to the bottom.
let g:gundo_preview_bottom = 1

" Map Gundo.
nnoremap <F5> :GundoToggle<cr>

" DetectIndent: Enable and configure.
augroup detectindent
  autocmd BufReadPost * :DetectIndent
augroup END
let g:detectindent_preferred_expandtab = 1
let g:detectindent_preferred_indent = 2

" UltiSnips: Compatibility with YouCompleteMe via SuperTab.
let g:ycm_key_list_select_completion = ['<C-n>', '<Down>']
let g:ycm_key_list_previous_completion = ['<C-p>', '<Up>']
let g:SuperTabDefaultCompletionType = '<C-n>'
let g:UltiSnipsExpandTrigger = "<tab>"
let g:UltiSnipsJumpForwardTrigger = "<tab>"
let g:UltiSnipsJumpBackwardTrigger = "<s-tab>"

" VimWiki: default location.
let g:vimwiki_list = [{
  \ 'path': '$HOME/Dropbox/wiki',
  \ 'template_path': '$HOME/Dropbox/wiki/templates',
  \ 'template_default': 'default',
  \ 'template_ext': '.html'}]

" Map Tagbar.
nnoremap <F8> :TagbarToggle<cr>

" Synastic configuration.
let g:syntastic_always_populate_loc_list = 1  " Make :lnext work.
let g:syntastic_html_checkers = ['']
let g:syntastic_javascript_checkers = ['gjslint', 'jshint']
let g:syntastic_javascript_gjslint_args = '--strict'
let g:syntastic_python_checkers = ['gpylint']

Most plugins above change slightly change daily Vim workflow: the way one navigates files, replaying actions, working with snippets, minor tweaks to editing - and I highly recommend at least skimming through README of plugins you’re interested in so you can incorporate the changes in your workflow.

I have a set of simple defaults I use everywhere, major changes being changing : to ; and moving my leader key to a spacebar. Everything else are tiny quality of life tweaks.

" => Editing -------------------------------------------------------------- {{{1

syntax on

" Indentation settings.
set autoindent
set expandtab
set shiftwidth=4
set softtabstop=4
set tabstop=4

" Disable backups and .swp files.
set nobackup
set noswapfile
set nowritebackup

" Semicolon is too long to type.
nnoremap ; :
vnoremap ; :

" Map leader key.
let mapleader = "\<Space>"

" Use system clipboard.
set clipboard=unnamedplus

" Enable wild menu (tab command autocompletion).
set wildmenu
set wildmode=list:longest,full

" Don't complain about unsaved files when switching buffers.
set hidden

" Make soft line breaks much better looking.
if v:version > 703
  set breakindent

" Pretty soft break character.
let &showbreak='↳ '

" => Looks ---------------------------------------------------------------- {{{1

set background=dark
colorscheme spacegray

" Set terminal window title and set it back on exit.
set title
let &titleold = getcwd()

" Shorten press ENTER to continue messages.
set shortmess=atI

" Show last command.
set showcmd

" Highlight cursor line.
set cursorline

" Ruler (line, column and % at the right bottom).
set ruler

" Display line numbers if terminal is wide enough.
if &co > 80
  set number

" Soft word wrap.
set linebreak

" Prettier display of long lines of text.
set display+=lastline

" Always show statusline.
set laststatus=2

" => Movement and search -------------------------------------------------- {{{1

" Ignore case when searching.
set ignorecase
set smartcase

" Fast split navigation.
nnoremap <C-j> <C-W><C-J>
nnoremap <C-k> <C-W><C-K>
nnoremap <C-l> <C-W><C-L>
nnoremap <C-h> <C-W><C-H>

" Absolute movement for word-wrapped lines.
nnoremap j gj
nnoremap k gk

" => Misc ----------------------------------------------------------------- {{{1

" Use Unix as the standart file type.
set ffs=unix,dos,mac

" Ignore compiled files.
set wildignore=*.o,*~,*.pyc,*.pyo

" Ignore virtualenv directory.
set wildignore+=env

" Fold using {{{n, where n is fold level
set foldmethod=marker

" => Fixes and hacks ------------------------------------------------------ {{{1

" Ignore mouse (in GVIM).
set mouse=c

" Fix backspace behavior in GVIM.
set bs=2

" NERDTree arrows in Windows.
if has("win32") || has("win64") || has("win32unix")
  let g:NERDTreeDirArrows = 0

" Increase lower status bar height in diff mode.
if &diff
  set cmdheight=2

" Unfold all files by default.
au BufRead * normal zR

I have some custom commands and shortcuts I’m using, but not too many. I find that I mostly just forget to use shortcuts I make, and I end up deleting lines from this section regularly.

" => Custom commands ------------------------------------------------------ {{{1

" Trim trailing whitespace in the file.
command TrimWhitespace %s/\s\+$//e

" Command to close current buffer without closing the window.
command Bd :bp | :sp | :bn | :bd

" => Leader shortcuts ----------------------------------------------------- {{{1

nnoremap <Leader>] <C-]>          " Jump to ctags tag definition.
nnoremap <Leader>p :CtrlP<cr>     " Fuzzy complete for files.
nnoremap <Leader>t :CtrlPTag<cr>  " Fuzzy complete for tags.
nnoremap <Leader>r :redraw!<cr>   " Redraw the screen (for visual glitches).
nnoremap <Leader>w :w<cr>         " Write a file.

Hope you find this useful and take away a few bits and pieces for your own workflow.